Articles Accessed Most Frequently

These are the Top 20 Papers (by download) for the 30 days preceding May 13, 2008. You can see the summaries if you are registered, or full text and PDFs if you have subscribed.

1.  PAP Inhibitor with In Vivo Efficacy Identified by Candida albicans Genetic Profiling of Natural Products
Bo Jiang, Deming Xu, John Allocco, Craig Parish, John Davison, Karynn Veillette, Susan Sillaots, Wenqi Hu, Roberto Rodriguez-Suarez, Steve Trosok, Li Zhang, Yang Li, Fariba Rahkhoodaee, Tara Ransom, Nick Martel, Hao Wang, Daniel Gauvin, Judyann Wiltsie, Douglas Wisniewski, Scott Salowe, Jennifer Nielsen Kahn, Ming-Jo Hsu, Robert Giacobbe, George Abruzzo, Amy Flattery, Charles Gill, Phil Youngman, Ken Wilson, Gerald Bills, Gonzalo Platas, Fernando Pelaez, Maria Teresa Diez, Sarah Kauffman, Jeff Becker, Guy Harris, Paul Liberator and Terry Roemer
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
2.  Mitochondria-Penetrating Peptides
Kristin L. Horton, Kelly M. Stewart, Sonali B. Fonseca, Qian Guo and Shana O. Kelley
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
3.  An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase
Sean W. Deacon, Alexander Beeser, Jami A. Fukui, Ulrike E.E. Rennefahrt, Cynthia Myers, Jonathan Chernoff and Jeffrey R. Peterson
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
4.  Solvent Structure and Hammerhead Ribozyme Catalysis
Monika Martick, Tai-Sung Lee, Darrin M. York and William G. Scott
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
5.  Optimizing Glycosyltransferase Specificity via “Hot Spot” Saturation Mutagenesis Presents a Catalyst for Novobiocin Glycorandomization
Gavin J. Williams, Randal D. Goff, Changsheng Zhang and Jon S. Thorson
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
6.  Structure-Based Design of a Superagonist Ligand for the Vitamin D Nuclear Receptor
Shinji Hourai, Luis Cezar Rodrigues, Pierre Antony, Bernardo Reina-San-Martin, Fabrice Ciesielski, Benjamin Claude Magnier, Kristina Schoonjans, Antonio Mouriño, Natacha Rochel and Dino Moras
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
7.  Toward Deciphering the Code to Aminergic G Protein-Coupled Receptor Drug Design
Edwin S. Tan, Eli S. Groban, Matthew P. Jacobson and Thomas S. Scanlan
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
8.  Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Sarbjot Sachdeva, Faik N. Musayev, Mamoun M. Alhamadsheh, J. Neel Scarsdale, H. Tonie Wright and Kevin A. Reynolds
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
9.  Ethylene Receptor Antagonists: Strained Alkenes Are Necessary but Not Sufficient
Michael C. Pirrung, Anthony B. Bleecker, Yoshihisa Inoue, Fernando I. Rodríguez, Norimitsu Sugawara, Takehiko Wada, Yunfan Zou and Brad M. Binder
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
10.  Structure-Activity Relationships of Antibacterial Acyl-Lysine Oligomers
Inna S. Radzishevsky, Tchelet Kovachi, Yaara Porat, Lior Ziserman, Fadia Zaknoon, Dganit Danino and Amram Mor
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
11.  Antidiabetic Activities of Triterpenoids Isolated from Bitter Melon Associated with Activation of the AMPK Pathway
Min-Jia Tan, Ji-Ming Ye, Nigel Turner, Cordula Hohnen-Behrens, Chang-Qiang Ke, Chun-Ping Tang, Tong Chen, Hans-Christoph Weiss, Ernst-Rudolf Gesing, Alex Rowland, David E. James and Yang Ye
[Summary]  [Fulltext]  [PDF] 
Mar 21, 2008 
15 (3)
12.  Studying Posttranslational Modifications by In-Cell NMR
G. Lippens, I. Landrieu and X. Hanoulle
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
13.  PAK'n It In: Identification of a Selective PAK Inhibitor
Gary M. Bokoch
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
14.  Sweetly Expanding Enzymatic Glycodiversification
David L. Jakeman
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
15.  The Tail of Mycolic Acids
Jeff Zhiqiang Lu and Sean T. Prigge
[Summary]  [Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
16.  Rational Design of Combination Enzyme Therapy for Celiac Sprue
Matthew Siegel, Michael T. Bethune, Jonathan Gass, Jennifer Ehren, Jiang Xia, Alexandre Johannsen, Tor B. Stuge, Gary M. Gray, Peter P. Lee and Chaitan Khosla
[Summary]  [Fulltext]  [PDF] 
June,  
13 (6)
17.  Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin
Ole A. Andersen, Amit Nathubhai, Mark J. Dixon, Ian M. Eggleston and Daan M.F. van Aalten
[Summary]  [Fulltext]  [PDF] 
Mar 21, 2008 
15 (3)
18.  High-Resolution NMR Analysis of the Conformations of Native and Base Analog Substituted Retroviral and LTR-Retrotransposon PPT Primers
Hye Young Yi-Brunozzi, Robert G. Brinson, Danielle M. Brabazon, Daniela Lener, Stuart F.J. Le Grice and John P. Marino
[Summary]  [Fulltext]  [PDF] 
Mar 21, 2008 
15 (3)
19.  In This Issue

[Fulltext]  [PDF] 
Apr 21, 2008 
15 (4)
20.  Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells
Wan Seok Yang and Brent R. Stockwell
[Summary]  [Fulltext]  [PDF] 
Mar 21, 2008 
15 (3)